PEPTIDEPEDIA.US

Independent · Evidence graded

The peptide reference that shows its evidence — and the tools to track your protocol.

26 monographs graded A to C by strength of human evidence, 6 long-form guides, and free clinical tools for logging progress and calculating doses.

Browse the database Open progress tracker

Evidence grading

Grade A
Multiple randomized controlled trials in humans
Grade B
Limited human trials or approved outside the US
Grade C
Preclinical or mechanistic data; no robust human trials

Browse by category

12 research areas, from FDA-approved incretins to experimental repair compounds.

View all 26 peptides

Weight Loss & Metabolic

4

GLP-1 and multi-receptor agonists studied for obesity and glycemic control.

Recovery & Repair

3

Tissue-repair and anti-inflammatory peptides used in injury protocols.

Growth Hormone & Performance

6

GHRH analogs and secretagogues affecting GH/IGF-1 axis and body composition.

Longevity & Immune

3

Mitochondrial, immune, and cellular-aging peptides with emerging evidence.

Cognitive & Mood

2

Neuropeptides modulating BDNF, GABA, and monoamine systems.

Skin & Aesthetics

2

Copper peptides and melanocortin analogs used for skin and pigmentation.

Hormones & Reproductive Health

1

Peptides acting on the hypothalamic-pituitary-gonadal axis and reproductive endocrine signaling.

Sleep & Neurological

1

Compounds investigated for sleep physiology, circadian regulation, and central nervous system signaling.

Mitochondrial & Metabolic Health

1

Mitochondrial-derived peptides studied in metabolic signaling, glucose handling, and energy homeostasis.

Neurological & Cognitive

1

Short peptides investigated in neurobiology, cellular stress, and cognitive-aging research.

Nerve Repair & Inflammation

1

Tissue-protective and anti-inflammatory compounds studied in neuropathy and repair signaling.

Cellular Energy & Longevity

1

Cofactors and metabolites central to redox metabolism, mitochondrial function, and aging biology.

Most referenced peptides

Semaglutide

Ozempic, Wegovy

Grade A

A long-acting GLP-1 receptor agonist approved for type 2 diabetes and chronic weight management, with the largest cardiovascular outcome dataset of any incretin peptide.

Weight Loss & MetabolicFDA approved (T2D, obesity)

Tirzepatide

Mounjaro, Zepbound

Grade A

A dual GIP/GLP-1 receptor agonist producing the largest weight reduction of any currently approved incretin therapy.

Weight Loss & MetabolicFDA approved (T2D, obesity, OSA)

Retatrutide

Grade B

A triple GLP-1/GIP/glucagon receptor agonist in late-stage trials, with the highest reported weight reduction to date in obesity studies.

Weight Loss & MetabolicInvestigational (Phase 3)

BPC-157

Grade C

A synthetic pentadecapeptide derived from a gastric protein, widely used for soft-tissue and gut healing on the strength of animal data.

Recovery & RepairNot approved; FDA bulks list category 2

TB-500

Thymosin Beta-4 fragment

Grade C

A synthetic fragment mimicking thymosin beta-4, used for tissue repair, flexibility, and inflammation control in research settings.

Recovery & RepairNot approved

GHK-Cu

Grade B

A naturally occurring copper tripeptide with the strongest dermatologic evidence base among cosmetic peptides.

Skin & AestheticsCosmetic ingredient

Clinical tools

Reference material tells you what a peptide does. These tools tell you what it is doing for you. Everything runs locally in your browser.

Progress tracker

Log weight, body fat, sleep, energy, mood, and side effects. Charted trends, summary deltas, and CSV export.

Reconstitution calculator

Turn vial strength, diluent volume, and target dose into exact insulin-syringe units and doses per vial.

Start with the fundamentals

All guides
12 min read

What Are Peptides? A Complete Beginner's Guide

Peptides are short chains of amino acids that act as cellular messengers. Here is how they work, how they differ from proteins and hormones, and what the categories actually mean.

 9 min read

Peptide Legality: FDA Status, Research Use, and Gray Areas

Legal status depends on approval pathway, compounding rules, and intended use — not molecular structure. Here is how the categories break down in the US.

 10 min read

Peptide Cycling: When Breaks Matter and When They Don't

Receptor desensitization, IGF-1 drift, and how cycling logic differs between GH secretagogues, repair peptides, and GLP-1 agonists.