Skin & AestheticsGrade B
GHK-Cu
A naturally occurring copper tripeptide with the strongest dermatologic evidence base among cosmetic peptides.
- Regulatory status
- Cosmetic ingredient
- Half-life
- N/A (topical)
- Route
- Topical (injection use unvalidated)
- Evidence
- Limited human trials or approved outside the US
Mechanism of action
Delivers copper intracellularly, stimulating collagen, elastin, and glycosaminoglycan synthesis while modulating gene expression.
Studied and reported uses
- Skin firmness and wrinkles
- Wound healing
- Hair follicle support
Dosing information
Topical1–3% serum, once or twice daily
NoteSeparate from direct vitamin C application
Ranges are reported from literature and clinical labeling for reference only. They are not a dosing recommendation.
Side effects
- Mild irritation
- Rare copper discoloration
Research evidence
Dermatology trials
Improved skin density and wrinkle depth vs vehicle.