All peptidesGrade AGrade BGrade B
Weight Loss & Metabolic
GLP-1 and multi-receptor agonists studied for obesity and glycemic control.
Tirzepatide
Mounjaro, Zepbound
A dual GIP/GLP-1 receptor agonist producing the largest weight reduction of any currently approved incretin therapy.
Weight Loss & MetabolicFDA approved (T2D, obesity, OSA)
Retatrutide
A triple GLP-1/GIP/glucagon receptor agonist in late-stage trials, with the highest reported weight reduction to date in obesity studies.
Weight Loss & MetabolicInvestigational (Phase 3)
AOD-9604
A modified fragment of human growth hormone (176-191) marketed for fat loss, with human trials that failed to separate from placebo.
Weight Loss & MetabolicNot approved