Cognitive & MoodGrade B
Semax
An ACTH(4-10) analog used in Russia for stroke recovery and cognitive disorders, notable for BDNF upregulation.
- Regulatory status
- Approved in Russia; not FDA approved
- Half-life
- Minutes (effects persist hours)
- Route
- Intranasal or subcutaneous
- Evidence
- Limited human trials or approved outside the US
Mechanism of action
Increases BDNF and NGF expression and modulates dopaminergic/serotonergic tone.
Studied and reported uses
- Cognitive performance
- Stroke rehabilitation
- Attention support
Dosing information
Reported range200–600 mcg daily intranasally
Ranges are reported from literature and clinical labeling for reference only. They are not a dosing recommendation.
Side effects
- Nasal irritation
- Overstimulation
- Irritability
Research evidence
Stroke trials
Improved neurological recovery scores (Russia).